Journal of Antimicrobial Chemotherapy, Vol 40, 279-281, Copyright © 1997 by The British Society for Antimicrobial Chemotherapy
M Lopez-Brea, D Domingo, I Sanchez and T Alarcon
The aim of this study was to determine the frequency of resistance to
amoxycillin, tetracycline, metronidazole and clarithromycin in 282
Helicobacter pylori clinical isolates from Spain and to evaluate the
evolution of resistance over the five years of this study. The overall
percentage of resistance was 19.9% for metronidazole and 3.5% for
clarithromycin. Resistance to metronidazole rose from 9% in 1991 to 21.6%
in 1995, although 33.3% resistance was found in 1993. Clarithromycin
resistance was not detected in 1991 or 1992 and the rate was 4%, 3.4% and
4.4% in 1993, 1994 and 1995, respectively. No amoxycillin or tetracycline
resistance was found.
ORIGINAL ARTICLES
Evolution of resistance to metronidazole and clarithromycin in Helicobacter pylori clinical isolates from Spain
Department of Microbiology, Hospital Universitario de la Princesa, Madrid, Spain.
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