Journal of Antimicrobial Chemotherapy, Vol 40, 275-277, Copyright © 1997 by The British Society for Antimicrobial Chemotherapy
S Sriskandan, A McKee, L Hall and J Cohen
We have tested the ability of Streptococcus pyogenes to produce
streptococcal pyrogenic exotoxin A (SPEA) and superantigenic activity in
the presence of sub-inhibitory concentrations of ampicillin and
clindamycin. After 6 h of culture, SPEA production by S. pyogenes was
higher in broths containing ampicillin (715.7 +/- 296.4 pg/10(6) cfu) than
in broths containing clindamycin (167.1 +/- 31.9 pg/10(6) cfu), a
difference that was not significant (P = 0.25). Promitogenic activity of
bacterial supernatants was also greater in ampicillin-treated cultures
(467.5 +/- 17.2 ccpm/10(6) cfu) than in clindamycin-treated cultures (169.2
+/- 8.9 ccpm/10(6) cfu), a difference that was highly significant (P =
0.0001). The data support the use of clindamycin in the treatment of
streptococcal toxic shock-like syndrome, in order to inhibit superantigen
synthesis.
ORIGINAL ARTICLES
Comparative effects of clindamycin and ampicillin on superantigenic activity of Streptococcus pyogenes
Department of Infectious Diseases, Royal Postgraduate Medical School, London, UK.
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