Journal of Antimicrobial Chemotherapy, Vol 40, 257-261, Copyright © 1997 by The British Society for Antimicrobial Chemotherapy
E Sjogren, GB Lindblom and B Kaijser
This study focused on the frequency of Campylobacter jejuni and
Campylobacter coli strains resistant to norfloxacin. Included were 1659
consecutive stool specimens isolated between 1992 and 1995, from as many
Swedish patients with diarrhoea. The patients were divided with regard to
place of infection and age. All strains were tested for susceptibility to
norfloxacin by means of disc diffusion test on blood- agar plates.
Norfloxacin-resistant strains (n = 310) were furthermore tested for
resistance to doxycycline and erythromycin. The Etest was used for
determination of MIC values of doxycyclin, erythromycin and norfloxacin of
81 of the strains. C. jejuni and C. coli isolations resistant to
norfloxacin were significantly more frequent among patients infected
abroad, especially in Spain and Thailand, compared with those infected in
Sweden, adults more often than children. The number of resistant strains
showed a yearly increase, and the difference between children and adults
was equalized in 1995. The MIC50 and MIC90 values for doxycycline and
erythromycin have increased markedly through the 4 years studied. This
study shows that norfloxacin, because of increased resistance, may have
limited utility for treatment of gastrointestinal infections caused by C.
jejuni and C. coli.
ORIGINAL ARTICLES
Norfloxacin resistance in Campylobacter jejuni and Campylobacter coli isolates from Swedish patients
Department of Clinical Bacteriology, Goteborg University, Sweden.
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