Journal of Antimicrobial Chemotherapy, Vol 40, 205-211, Copyright © 1997 by The British Society for Antimicrobial Chemotherapy
MA Cohen, MD Huband, JW Gage, SL Yoder, GE Roland and SJ Gracheck
Clinafloxacin and trovafloxacin are two new fluoroquinolones for which few
comparative data are available. When MICs of ciprofloxacin against
Gram-positive and Gram-negative nosocomial species were compared,
clinafloxacin was the most potent although trovafloxacin was also more
active than ciprofloxacin against Staphylococcus aureus and enterococci.
All three drugs were bactericidal. Clinafloxacin displayed the lowest
frequency of resistance, approximating 10(-11). Development of resistance
studies over 13-14 passages in the presence of drug revealed a 32-fold
increase in MIC of clinafloxacin against S. aureus compared with 512- and
1024-fold for trovafloxacin and ciprofloxacin respectively, although the
three drugs were comparable against Enterococcus faecalis and the
Gram-negative bacilli.
ORIGINAL ARTICLES
In-vitro activity of clinafloxacin, trovafloxacin, and ciprofloxacin
Therapeutics Department, Parke-Davis Pharmaceutical Research, Division of Warner Lambert Company, Ann Arbor, MI 48105-2495, USA.
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