Journal of Antimicrobial Chemotherapy, Vol 40, 85-90, Copyright © 1997 by The British Society for Antimicrobial Chemotherapy
A Bonnefoy, AM Girard, C Agouridas and JF Chantot
Ketolides belong to a new class of semi-synthetic 14-membered-ring
macrolides, which differ from erythromycin A by having a 3-keto group
instead of the neutral sugar L-cladinose. The ability of these molecules
and their L-cladinose counterparts to induce MLS(B) resistance in
staphylococci (one strain) and streptococci (two strains) was investigated
using a disc agar susceptibility method as well as measuring induction
kinetics. All 14- and 15-membered ring macrolides tested showed inducing
activity. In contrast, ketolides were clearly unable to induce MLS(B)
resistance, a result consistent with the high in-vitro activity of this new
class of antibiotics against erythromycin A-inducible resistant bacteria.
ORIGINAL ARTICLES
Ketolides lack inducibility properties of MLS(B) resistance phenotype
Antiinfective Research Department, Roussel UCLAF, Romainville, France.
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