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Journal of Antimicrobial Chemotherapy, Vol 40, 121-124, Copyright © 1997 by The British Society for Antimicrobial Chemotherapy

ORIGINAL ARTICLES

The pharmacokinetics of intravenous ciprofloxacin 400 mg 12 hourly in patients with severe sepsis: the effect of renal function and intra- abdominal disease

EM Jones, CM McMullin, AJ Hedges, AM Lovering, LO White, DS Reeves and AP MacGowan
Bristol Centre for Antimicrobial Research and Evaluation, Southmead Health Services NHS Trust and the University of Bristol, Southmead Hospital, Westbury-on-Trym, UK. lesassays@ukneqasaa.win-uk.net

Serum concentrations of ciprofloxacin were reviewed in 22 patients given ciprofloxacin 400 mg intravenously 12 hourly for severe infection. No dosage modifications were made in patients with renal impairment. Patients who had either bowel or liver pathology in addition to renal failure had significantly higher serum concentrations than all other patients. Dosage reduction of ciprofloxacin in patients with severe sepsis and impaired renal function is not required unless they have co-existent intra-abdominal disease.
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