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Journal of Antimicrobial Chemotherapy, Vol 40, 117-119, Copyright © 1997 by The British Society for Antimicrobial Chemotherapy

ORIGINAL ARTICLES

Clinical response to ketoconazole of HIV-related oral candidosis is predicted by Odds' relative growth method of susceptibility testing

JD Cartledge, J Midgley and BG Gazzard
Department of HIV & Genito-Urinary Medicine, St Stephen's Centre, Chelsea & Westminster Healthcare NHS Trust, London, UK.

In-vitro ketoconazole susceptibility was assessed by measuring an isolate's relative growth in medium containing a fixed concentration of ketoconazole as a percentage of growth in drug-free medium. One hundred specimens from HIV-positive patients with candidosis were tested. Each patient's response was assessed following one week's treatment with ketoconazole 400 mg/day. A relative growth in ketoconazole of >75% predicted clinical failure of ketoconazole with a specificity of 97% and sensitivity of 79%.
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This article has been cited by other articles:


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J. H. Rex, M. A. Pfaller, T. J. Walsh, V. Chaturvedi, A. Espinel-Ingroff, M. A. Ghannoum, L. L. Gosey, F. C. Odds, M. G. Rinaldi, D. J. Sheehan, et al.
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 J Antimicrob ChemotherHome page
J. D. Cartledge, J. Midgley, and B. G. Gazzard
Non-albicansoralcandidosis in HIV-positive patients
J. Antimicrob. Chemother., March 1, 1999; 43(3): 419 - 422.
[Abstract] [Full Text] [PDF]


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