Journal of Antimicrobial Chemotherapy, Vol 40, 109-112, Copyright © 1997 by The British Society for Antimicrobial Chemotherapy
D Law, CB Moore and DW Denning
Several methods of susceptibility testing were compared for their ability
to detect amphotericin B resistance among yeast isolates, including
isolates known to be amphotericin-B-resistant in an animal model. A
microtitre MIC method using antibiotic medium no. 3 and Etest strips were
able to discriminate susceptible and resistant isolates. A disc
susceptibility test was also able to identify resistant isolates and this
method may be suitable for routine use as a screening test. A survey of
resistance in 644 clinical isolates showed that the incidence of elevated
MICs (> or = 0.25 mg/L) was only 1.2%.
ORIGINAL ARTICLES
Amphotericin B resistance testing of Candida spp.: a comparison of methods
Department of Microbiology, University of Manchester, Hope Hospital, Salford, UK.
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