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Journal of Antimicrobial Chemotherapy, Vol 40, 105-108, Copyright © 1997 by The British Society for Antimicrobial Chemotherapy

ORIGINAL ARTICLES

Decreased susceptibility to imipenem among penicillin-resistant Streptococcus pneumoniae [published erratum appears in J Antimicrob Chemother 1997 Sep;40(3):462]

A Pikis, JA Donkersloot, S Akram, JM Keith, JM Campos and WJ Rodriguez
Department of Infectious Diseases, Children's National Medical Center, Washington, DC 20010-2970, USA.

We assessed the antimicrobial susceptibilities of 59 penicillin- intermediate or penicillin-resistant pneumococci. All strains were susceptible to vancomycin and rifampicin. The frequency of strains with decreased susceptibility to cefotaxime, chloramphenicol, imipenem and meropenem was 15, 31, 47 and 49% respectively. The high percentage of penicillin-intermediate or penicillin-resistant Streptococcus pneumoniae with decreased susceptibility to third-generation cephalosporins, chloramphenicol and carbapenems limits the therapeutic options for the treatment of invasive pneumococcal infections and particularly of meningitis.
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