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Journal of Antimicrobial Chemotherapy (1978) 4, 255-256
© 1978 The British Society for Antimicrobial Chemotherapy

other

Pharmacokinetics of piperacillin following intravenous administration

M. A. L. Evans, P. Wilson, T. Leung and J. D. Williams

Department of Medical Microbiology, The London Hospital Medical College London El 2AD, England

accepted 5 January 1978

Piperacillin was given to 12 male volunteers as a bolus, infusion or in combination of bolus and infusion in 4 dosage regimens. Serum and urine samples were taken for assay of piperacillin and pharmacokinetic parameters were derived. Following bolus injection of 15, 30 and 60 mg/kg peak serum levels of 138, 205 and 520 µg/ml were obtained. Using infusion at a rate of 7.5, 15 and 30 mg/h steady state piperacillin levels were 25, 50 and 130µg/ml respectively. No significant biochemical haematological or clinical change was noted following administration. Piperacillin was largely excreted in the urine and the possible advantages of different modes of administration are discussed.


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