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Journal of Antimicrobial Chemotherapy (1978) 4, 233-240
© 1978 The British Society for Antimicrobial Chemotherapy

research-article

Mucoid Pseudomonas aeruginosa and cystic fibrosis: resistance of the mucoid form to carbenicillin, flucloxacillin and tobramycin and the isolation of mucoid variants in vitro

J. R. W. Govan and Janet A. M. Fyfe

Department of Bacteriology, University of Edinburgh, Medical School Teviot Place, Edinburgh EH8 9AG, Scotland

accepted 14 December 1977

Mucoid strains of Pseudomonas aeruginosa isolated from the sputa of patients with cystic fibrosis or in vitro through selection with phage were more resistant to carbenicillin, flucloxacillin and tobramycin and more sensitive to tetracycline than related non-mucoid strains. The observations led to the development of a technique for the isolation of mucoid variants in vitro based on enhanced resistance to carbenicillin. Mucoid variants were isolated from various strains of Ps. aeruginosa and the exopolysaccharide found to be similar to that obtained from mucoid Ps. aeruginosa isolated from patients with cystic fibrosis.


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