Journal of Antimicrobial Chemotherapy, Vol 39, 93-98, Copyright © 1997 by The British Society for Antimicrobial Chemotherapy
N Berthaud, Y Huet, N Diallo and JF Desnottes
In-vitro and in-vivo efficacies of quinupristin/dalfopristin and vancomycin
against methicillin-resistant Staphylococcus aureus (MRSA) responsible for
endocarditis have been compared. The following parameters were
investigated: MIC, activity across a platelet-fibrin matrix simulating
cardiac vegetations, killing of bacteria on the cardiac vegetations
resulting from experimental aortic valve endocarditis in an animal model,
and concentrations of antibiotics in the serum and vegetations of infected
rabbits. The same bacterial strain was used for all experiments. The MICs
of quinupristin/dalfopristin and vancomycin were 0.25 and 1 mg/L,
respectively. When tested for their ability to penetrate platelet- fibrin
matrices, both drugs were bactericidal against the MRSA strain (> or = 2
log10 cfu/mL decrease in 2 h). Both drugs significantly reduced the
bacterial counts in vegetations in infected rabbits. Within 12 h of
intravenous administration of 20 mg/kg, concentrations of
quinupristin/dalfopristin decreased from 5.3 to < 0.10 mg/L in serum and
from 12.9 to < 1 mg/kg in the valve vegetations. Although the
concentrations of vancomycin in the serum and the infected tissue were
higher than those of quinupristin/dalfopristin, the latter combination was
equally effective, perhaps because its bactericidal activity is rapid and
because it can more easily penetrate the cardiac vegetations.
ORIGINAL ARTICLES
Antistaphylococcal activities of quinupristin/dalfopristin in vitro across platelet-fibrin matrices and in experimental endocarditis
Rhone-Poulenc Rorer S.A., Centre de Recherche, Vitry-sur-Seine, France.
CiteULike 
Connotea 
Del.icio.us What's this?
This article has been cited by other articles:
|
|
 |
|
  G. Krishna, J. C. Kisicki, S. Olsen, D. M. Grasela, and Z. Wang The Effect of Omeprazole on the Bioavailability and Safety of Garenoxacin in Healthy Volunteers J. Clin. Pharmacol., May 1, 2007; 47(5): 628 - 632. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 B. Amorena, E. Gracia, M. Monzon, J. Leiva, C. Oteiza, M. Perez, J.-L. Alabart, and J. Hernandez-Yago Antibiotic susceptibility assay for Staphylococcus aureus in biofilms developed in vitro J. Antimicrob. Chemother., July 1, 1999; 44(1): 43 - 55. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. Lober, S. Ziege, M. Rau, G. Schreiber, A. Mignot, P. Koeppe, and H. Lode Pharmacokinetics of Gatifloxacin and Interaction with an Antacid Containing Aluminum and Magnesium Antimicrob. Agents Chemother., May 1, 1999; 43(5): 1067 - 1071. [Abstract] [Full Text]
|
|