Journal of Antimicrobial Chemotherapy, Vol 39, 47-51, Copyright © 1997 by The British Society for Antimicrobial Chemotherapy
K Sieradzki and A Tomasz
We tested the effect of a number of mechanistically distinct antibacterial
agents on the expression of methicillin resistance in a highly and
homogeneously resistant strain of methicillin-resistant Staphylococcus
aureus. The antibiotics, used at 0.25 x MIC, included inhibitors of early
steps in peptidoglycan synthesis (fosfomycin, beta- chloro-D-alanine,
D-cycloserine); bacitracin; teicoplanin and vancomycin; beta-lactam
inhibitors chosen on the basis of their relatively selective affinities for
penicillin-binding proteins 1, 2, 3 and 4 of S. aureus (imipenem,
cefotaxime, cephradine and cefoxitin); compounds that inhibit various steps
in protein synthesis (tetracycline, chloramphenicol, gentamicin,
erythromycin and quinupristin/dalfopristin) and an inhibitor of DNA gyrase
(temafloxacin). All inhibitors of early cell wall synthesis caused
reduction of methicillin resistance and change from the homogeneous to the
heterogeneous methicillin-resistant phenotype. Similar effects were
obtained with only cephradine out of the four beta-lactams tested, and with
erythromycin and quinupristin/dalfopristin as well. The other inhibitors of
protein synthesis and DNA gyrase had no effect.
ORIGINAL ARTICLES
Suppression of beta-lactam antibiotic resistance in a methicillin- resistant Staphylococcus aureus through synergic action of early cell wall inhibitors and some other antibiotics
Rockefeller University, New York, NY 10021, USA.
CiteULike 
Connotea 
Del.icio.us What's this?
This article has been cited by other articles:
|
|
 |
|
  A. Antignac and A. Tomasz Reconstruction of the Phenotypes of Methicillin-Resistant Staphylococcus aureus by Replacement of the Staphylococcal Cassette Chromosome mec with a Plasmid-Borne Copy of Staphylococcus sciuri pbpD Gene Antimicrob. Agents Chemother., February 1, 2009; 53(2): 435 - 441. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. Domenech, S. Ribes, C. Cabellos, F. Taberner, F. Tubau, M. A. Dominguez, A. Montero, J. Linares, J. Ariza, and F. Gudiol Experimental study on the efficacy of combinations of glycopeptides and {beta}-lactams against Staphylococcus aureus with reduced susceptibility to glycopeptides J. Antimicrob. Chemother., October 1, 2005; 56(4): 709 - 716. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
V. Huang and M. J. Rybak Pharmacodynamics of Cefepime Alone and in Combination with Various Antimicrobials against Methicillin-Resistant Staphylococcus aureus in an In Vitro Pharmacodynamic Infection Model Antimicrob. Agents Chemother., January 1, 2005; 49(1): 302 - 308. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
K. H. Rand and H. J. Houck Synergy of Daptomycin with Oxacillin and Other {beta}-Lactams against Methicillin-Resistant Staphylococcus aureus Antimicrob. Agents Chemother., August 1, 2004; 48(8): 2871 - 2875. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. Brown and B. B Freeman III Combining Quinupristin/Dalfopristin with Other Agents for Resistant Infections Ann. Pharmacother., April 1, 2004; 38(4): 677 - 685. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. David Synergic activity of D-cycloserine and {beta}-chloro-D-alanine against Mycobacterium tuberculosis J. Antimicrob. Chemother., February 1, 2001; 47(2): 203 - 206. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 L. Good, R. Sandberg, O. Larsson, P. E. Nielsen, and C. Wahlestedt Antisense PNA effects in Escherichia coli are limited by the outer-membrane LPS layer Microbiology, October 1, 2000; 146(10): 2665 - 2670. [Abstract] [Full Text]
|
|
|
|
|
|
J. Vouillamoz, J. M. Entenza, C. Féger, M. P. Glauser, and P. Moreillon Quinupristin-Dalfopristin Combined with beta -Lactams for Treatment of Experimental Endocarditis Due to Staphylococcus aureus Constitutively Resistant to Macrolide-Lincosamide-Streptogramin B Antibiotics Antimicrob. Agents Chemother., July 1, 2000; 44(7): 1789 - 1795. [Abstract] [Full Text]
|
|
|
|
|
|
M. W. Climo, R. L. Patron, and G. L. Archer Combinations of Vancomycin and beta -Lactams Are Synergistic against Staphylococci with Reduced Susceptibilities to Vancomycin Antimicrob. Agents Chemother., July 1, 1999; 43(7): 1747 - 1753. [Abstract] [Full Text]
|
|
|
|
 |
|
 K. Sieradzki, R. B. Roberts, S. W. Haber, and A. Tomasz The Development of Vancomycin Resistance in a Patient with Methicillin-Resistant Staphylococcus aureus Infection N. Engl. J. Med., February 18, 1999; 340(7): 517 - 523. [Full Text] [PDF]
|
|
|
|
|
|
M. Bergeret and J. Raymond In-vitro bactericidal activity of cefpirome and cefamandole in combination with glycopeptides against methicillin-resistant Staphylococcus aureus J. Antimicrob. Chemother., February 1, 1999; 43(2): 291 - 294. [Abstract] [Full Text] [PDF]
|
|