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Journal of Antimicrobial Chemotherapy, Vol 39, 811-814, Copyright © 1997 by The British Society for Antimicrobial Chemotherapy

JOURNAL ARTICLE

Postantibiotic effect of trovafloxacin on Pseudomonas aeruginosa

FJ Boswell, JM Andrews and R Wise
Department of Medical Microbiology, City Hospital NHS Trust, Birmingham, UK.

The postantibiotic effect (PAE) of trovafloxacin (CP 99,219) was investigated with six strains of Pseudomonas aeruginosa at concentrations equivalent to 0.5, 1, 2 and 4 x MIC. Trovafloxacin exhibited a significant PAE with four out of the six strains of P. aeruginosa studied. The PAE values obtained for trovafloxacin with P. aeruginosa ranged from 0.3 h to 2.3 h, increasing with increased exposure time and trovafloxacin concentration.
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