Journal of Antimicrobial Chemotherapy, Vol 39, 797-802, Copyright © 1997 by The British Society for Antimicrobial Chemotherapy
JM Andrews, D Honeybourne, NP Brenwald, D Bannerjee, M Iredale, B Cunningham and R Wise
Concentrations of trovafloxacin were measured in serum, alveolar
macrophages, epithelial lining fluid and bronchial mucosa following single
and multiple oral doses. Concentrations were determined using a
microbiological assay method. There were 18 subjects in the single dose and
nine subjects in the multiple dose groups. After single dosing, mean
concentrations in serum, alveolar macrophages, epithelial lining fluid and
bronchial mucosa at 6, 12 and 24 h were as follows: 6 h, 1.41 mg/L, 19.06
mg/L, 3.01 mg/L and 1.52 mg/kg; 12 h, 0.85 mg/L, 16.22 mg/L, 4.8 mg/L and
1.01 mg/kg; 24 h, 0.37 mg/L, 10.23 mg/L, 0.93 mg/L, and no measurable
concentration, respectively. After multiple dosing (approximately 6 h
post-dose) the corresponding concentrations were 1.47 mg/L, 34.3 mg/L,
10.21 mg/L and 1.67 mg/kg, respectively. These concentrations exceed the
MIC90s for the common respiratory pathogens, Haemophilus influenzae 0.06
mg/L, Moraxella catarrhalis 0.008 mg/L and Streptococcus pneumoniae 0.12
mg/L and suggest that trovafloxacin should be efficacious in the treatment
of community- and hospital- acquired respiratory infections.
JOURNAL ARTICLE
Concentrations of trovafloxacin in bronchial mucosa, epithelial lining fluid, alveolar macrophages and serum after administration of single or multiple oral doses to patients undergoing fibre-optic bronchoscopy
Department of Medical Microbiology and Thoracic Medicine, City Hospital NHS Trust, Birmingham, UK.
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