Journal of Antimicrobial Chemotherapy, Vol 39, 757-762, Copyright © 1997 by The British Society for Antimicrobial Chemotherapy
J Vila, J Ruiz, P Goni and T Jimenez de Anta
Mutations in the parC gene, which encodes a subunit of topoisomerase IV,
were determined in 21 epidemiologically unrelated clinical isolates of
Acinetobacter baumannii. Our studies highlight the conserved sequences in
the quinolone-resistance-determining region of the parC gene from A.
baumannii and other bacteria. Nine of ten isolates with MICs of
ciprofloxacin of > or = 32 mg/L showed a change of Ser80 to Leu and one
showed a change of Glu84 to Lys. These results suggest that ParC from A.
baumannii is a secondary target for quinolones and that mutations at
residues Ser80 and Glu84, when combined with mutations at Ser83 of GyrA,
may render A. baumannii highly resistant to quinolones.
JOURNAL ARTICLE
Quinolone-resistance mutations in the topoisomerase IV parC gene of Acinetobacter baumannii
Department of Microbiology, Hospital Clinic, School of Medicine, University of Barcelona, Spain. vila@microclinic.med.ub.es
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