Journal of Antimicrobial Chemotherapy, Vol 39, 725-730, Copyright © 1997 by The British Society for Antimicrobial Chemotherapy
M Maurin and D Raoult
Levofloxacin, the L-isomer of ofloxacin, is approximately twice as active
as ofloxacin against most Gram-positive and Gram-negative bacteria, and has
improved intracellular pharmacokinetic and pharmacodynamic properties. The
present work deals with the in-vitro activity of levofloxacin against the
obligate intracellular bacteria Rickettsia rickettsii, Rickettsia conorii,
'Israeli spotted fever group rickettsia' (Israeli SFGR) and Coxiella
burnetii. Fluoroquinolones, including ofloxacin, have previously been shown
to be bacteriostatic against Rickettsia spp. and C. burnetii in vitro. They
are reliable alternatives to tetracycline therapy for Mediterranean spotted
fever, scrub typhus and acute Q fever. Levofloxacin was bacteriostatic
against R. rickettsii, R. conorii and the Israeli SFGR at concentrations of
0.5- 1 mg/L, as determined by both a plaque assay and a dye uptake assay.
It was also bacteriostatic against C. burnetii isolates, including the Nine
Mile, Priscilla and Q212 strains, at concentrations of 0.5-2 mg/L, as
determined using the shell vial assay. Overall, levofloxacin could inhibit
rickettsial growth at concentrations equal to or half of those necessary
for growth inhibition by ofloxacin. Levofloxacin was not bactericidal
against C. burnetii at concentrations up to 4 mg/L.
JOURNAL ARTICLE
Bacteriostatic and bactericidal activity of levofloxacin against Rickettsia rickettsii, Rickettsia conorii, 'Israeli spotted fever group rickettsia' and Coxiella burnetii
Unite des rickettsies, CNRS EP J0054, Faculte de medecine, Marseille, France.
CiteULike 
Connotea 
Del.icio.us What's this?
This article has been cited by other articles:
|
|
 |
|
  J. STENOS, S. R. GRAVES, and N. B. UNSWORTH A HIGHLY SENSITIVE AND SPECIFIC REAL-TIME PCR ASSAY FOR THE DETECTION OF SPOTTED FEVER AND TYPHUS GROUP RICKETTSIAE Am J Trop Med Hyg, December 1, 2005; 73(6): 1083 - 1085. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 R. E. Brennan and J. E. Samuel Evaluation of Coxiella burnetii Antibiotic Susceptibilities by Real-Time PCR Assay J. Clin. Microbiol., May 1, 2003; 41(5): 1869 - 1874. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J.-M. Rolain, M. Maurin, and D. Raoult Bacteriostatic and Bactericidal Activities of Moxifloxacin against Coxiella burnetii Antimicrob. Agents Chemother., January 1, 2001; 45(1): 301 - 302. [Abstract] [Full Text]
|
|
|
|
 |
|
 M. Maurin and D. Raoult Q Fever Clin. Microbiol. Rev., October 1, 1999; 12(4): 518 - 553. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. L. Faul, R. L. Doyle, P. N. Kao, and S. J. Ruoss Tick-Borne Pulmonary Disease: Update on Diagnosis and Management Chest, July 1, 1999; 116(1): 222 - 230. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. M. Rolain, M. Maurin, G. Vestris, and D. Raoult In Vitro Susceptibilities of 27 Rickettsiae to 13 Antimicrobials Antimicrob. Agents Chemother., July 1, 1998; 42(7): 1537 - 1541. [Abstract] [Full Text]
|
|