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Journal of Antimicrobial Chemotherapy, Vol 39, 427-430, Copyright © 1997 by The British Society for Antimicrobial Chemotherapy

JOURNAL ARTICLE

In-vivo activity and tolerance of conventional formulation versus fat emulsion formulation of amphotericin B in experimental disseminated candidiasis in neutropenic rabbits

P Chavanet, M Duong, M Buisson, H Hamel, C Dubois, A Bonnin and H Portier
Infectious Diseases Department, Hopital du Bocage, Dijon, France.

Amphotericin B can cause significant toxicity but this can be reduced by direct dilution into a fat emulsion (Intralipid). To investigate the potential use of amphotericin B diluted in Intralipid, a study was made of its activity in the treatment of subacute disseminated candidiasis in persistently granulocytopenic rabbits, compared with the same dose of amphotericin B diluted in dextrose. Amphotericin-B-fat emulsion was at least as effective as amphotericin-B-dextrose. Amphotericin-B-fat emulsion was significantly more effective than amphotericin-B-dextrose therapy in reducing candida colony counts in both kidney and liver tissues (P < 0.05). Furthermore, amphotericin-B-fat emulsion was found less toxic on the renal function than conventional amphotericin B (P < 0.05). From these experimental results, we conclude that amphotericin-B- fat emulsion (Intralipid) was at least as effective and less toxic than conventional amphotericin B.
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L. C. Souza and A. Campa
Pharmacological parameters of intravenously administered amphotericin B in rats: comparison of the conventional formulation with amphotericin B associated with a triglyceride-rich emulsion
J. Antimicrob. Chemother., July 1, 1999; 44(1): 77 - 84.
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