Journal of Antimicrobial Chemotherapy, Vol 39, 419-422, Copyright © 1997 by The British Society for Antimicrobial Chemotherapy
P Pieroni, J Goodfellow, L Reesor, M Louie and AE Simor
The in-vitro susceptibilities of 1658 blood culture isolates to
ciprofloxacin and 13 other antimicrobial agents were determined, and
compared with the results for isolates obtained before and after the
availability of ciprofloxacin in 1989. Only six (0.6%) of 995
Enterobacteriaceae were resistant to the fluoroquinolones tested; all of
the ciprofloxacin-resistant strains were isolated after 1989 (P = 0.04). No
significant increase in ciprofloxacin resistance was found in Pseudomonas
aeruginosa or Acinetobacter spp. No resistance to ciprofloxacin was found
in 124 Staphylococcus aureus isolates prior to 1989, but five (2.4%) of 208
S. aureus strains recovered after 1989 were ciprofloxacin-resistant (P =
0.16). Rates of resistance to ciprofloxacin and other antimicrobial agents
commonly used to treat bacteraemic infections have remained relatively low
in this Canadian teaching hospital over the past 16 years.
JOURNAL ARTICLE
Antimicrobial susceptibilities of blood culture isolates obtained before and after the introduction of ciprofloxacin
Department of Microbiology, University of Toronto, Ontario, Canada.
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