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Journal of Antimicrobial Chemotherapy, Vol 39, 415-418, Copyright © 1997 by The British Society for Antimicrobial Chemotherapy

JOURNAL ARTICLE

Pharmacodynamic properties of faropenem demonstrated by studies of time- kill kinetics and postantibiotic effect

FJ Boswell, JM Andrews and R Wise
Department of Medical Microbiology, City Hospital NHS Trust, Birmingham, UK.

The pharmacodynamic properties of faropenem, a new oral penem antibiotic, were investigated by studying time-kill kinetics and postantibiotic effect. Time-kill kinetics were employed against strains of Bacteroides fragilis, Escherichia coli, Staphylococcus aureus, Haemophilus influenzae, Moraxella catarrhalis and Streptococcus pyogenes. The postantibiotic effects of faropenem were studied using strains of E. coli, S. aureus, H. influenzae and Streptococcus pneumoniae. The time-kill kinetic data demonstrated that faropenem has bactericidal activity. Faropenem exhibited a significant postantibiotic effect against all strains except H. influenzae.
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