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Journal of Antimicrobial Chemotherapy, Vol 39, 273-276, Copyright © 1997 by The British Society for Antimicrobial Chemotherapy

JOURNAL ARTICLE

Comparative therapeutic efficacy of clinafloxacin in leucopenic mice

MA Shapiro, JA Dever, JC Sesnie and SR VanderRoest
Department of Infectious Diseases, Parke-Davis Pharmaceutical Research, Ann Arbor, MI 48105, USA.

A cyclophosphamide-induced leucopenic mouse model was used to compare the therapeutic efficacy of clinafloxacin, a fluoroquinolone in clinical trials, with that of ciprofloxacin and imipenem/cilastatin, two clinically relevant standard drugs. Acute systemic infections induced by Escherichia coli, Pseudomonas aeruginosa, a penicillin- resistant Staphylococcus aureus and a methicillin-resistant S. aureus (MRSA) were used to evaluate drug efficacy. Median protective values (PD50) with 95% confidence limits were determined in both leucopenic and normal mice. Results show that clinafloxacin is potentially a useful agent in the treatment of neutropenic patients.
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L. M. Ednie, M. R. Jacobs, and P. C. Appelbaum
Comparative Activities of Clinafloxacin against Gram-Positive and -Negative Bacteria
Antimicrob. Agents Chemother., May 1, 1998; 42(5): 1269 - 1273.
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