Journal of Antimicrobial Chemotherapy, Vol 39, 163-167, Copyright © 1997 by The British Society for Antimicrobial Chemotherapy
I Pujol, J Guarro, J Gene and J Sala
The MICs of amphotericin B, miconazole, ketoconazole, flucytosine,
itraconazole and fluconazole for 19 isolates of Fusarium oxysporum, 16
Fusarium solani, seven Fusarium verticilliodes, four Fusarium proliferatum,
four Fusarium dimerum, three Fusarium equiseti, and one each of the
following species: Fusarium graminearum, Fusarium chlamydosporum, Fusarium
semitectum, Fusarium avenaceum and Fusarium subglutinans were determined by
a broth microdilution method. Thirty- eight of these isolates were of
clinical origin and 20 from environmental sources. In general, Fusarium
spp. strains showed resistance to all the antifungals tested. However, the
most active agent was amphotericin B. Fluconazole and flucytosine were not
active against any of the isolates tested. A correlation study of in-vitro
testing with in-vivo outcome of amphotericin B of the cases of disseminated
fusarium infections published is reported.
JOURNAL ARTICLE
In-vitro antifungal susceptibility of clinical and environmental Fusarium spp. strains
Laboratori de Microbiologia, Hospital Universitari Sant Joan de Reus, Spain.
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