Journal of Antimicrobial Chemotherapy, Vol 39, 129-134, Copyright © 1997 by The British Society for Antimicrobial Chemotherapy
A Hamid, H Uematsu, N Sato, K Kota, M Iwaku and E Hoshino
The metabolism of phenylalanine and leucine by Peptostreptococcus
anaerobius and the effects of metronidazole on this metabolism were
studied. The cells metabolized both phenylalanine and leucine under strict
anaerobic conditions and produced hydroxylated products (i.e. phenyllactate
from phenylalanine and hydroxyisocaproate from leucine). Other products
were phenylpropionate, cinnamate and phenylacetate from phenylalanine;
isocaproate, alpha-ketoisocaproate and isovalerate from leucine.
Metronidazole inhibited the production of all end-products, with the
exception of phenyllactate and hydroxyisocaproate which were increased.
Similarly, when the reaction was carried out aerobically, the cells also
metabolized both phenylalanine and leucine and all end- products were
inhibited again with the exception of phenyllactate and hydroxyisocaproate.
Our results suggest that the inhibitory mode of metronidazole is similar to
that of oxygen.
JOURNAL ARTICLE
Inhibitory effects of metronidazole on anaerobic metabolism of phenylalanine and leucine by Peptostreptococcus anaerobius
Department of Operative Dentistry and Endodontics, Niigata University School of Dentistry, Japan.
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