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Journal of Antimicrobial Chemotherapy, Vol 39, 99-101, Copyright © 1997 by The British Society for Antimicrobial Chemotherapy

JOURNAL ARTICLE

The effect of artemisinin on granulocyte function assessed by flow cytometry

C Wenisch, B Parschalk, K Zedwitz-Liebenstein, W Wernsdorfer and W Graninger
Department of Infectious Diseases, Internal Medicine I, University Hospital of Vienna, Austria.

The effect of dihydroartemisinin, artemisinin and artesunate (0.1, 0.5, 5 and 50 mg/L) on phagocytic function and release of reactive oxygen products by neutrophils was studied by flow cytometry. Incubation with dihydroartemisinin, artemisinin and artemether resulted in a decreased capacity to phagocytose Escherichia coli (0.1-50 mg/L: 62-40%, 66-32% and 59-47% of the control values, respectively; P < 0.001 for all). Conversely, the derivatives enhanced the intracellular generation of reactive oxygen intermediates (0.1-50 mg/L: 146-140%, 174-197% and 188- 136% of the control values, respectively; P < 0.001 for all). Artemisia derivatives enhance the reactive oxygen response of neutrophils but depress their phagocytic ability at therapeutic blood levels.
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