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Journal of Antimicrobial Chemotherapy (1996) 38, 871-876
© 1996 The British Society for Antimicrobial Chemotherapy

brief-report

Enteric absorption of ciprofloxacin during tube feeding in the critically ill

Stephen M. Cohn*, Mark D. Sawyer, Gerard A. Burns, Concertina Tolomeo and Kerry A. Milner

Section of Trauma/Surgical Critical Care, Department of Surgery, Yale School of Medicine 333 Cedar Street, New Haven, CT 06520, USA

Received 21 March 1996; returned 9 April 1995; accepted 24 May 1996

*Tel: +1(203)-785-2572; Fax +1(203)-785-3950

To determine the pharmacokinetic properties of ciprofloxacin in the critically ill, we studied seven mechanically ventilated patients with pneumonia during entcral feedings. Subjects received ciprofloxacin 750 mg every 12 h via nasogastric tube and serial serum drug concentrations were measured after the first and fourth dose. After the initial dose, the maximum serum concentration ranged from 1.24–3.06 mg/L, and the area under the time curve from 0–12 h ranged from 3.2–19.65 mg.h/L. Similar levels were noted after dose four. Gastrointestinal absorption of ciprofloxacin in tube fed critically ill patients was decreased, but well above MIC values for many pathogenic bacteria.


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