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Journal of Antimicrobial Chemotherapy (1996) 38, 853-858
© 1996 The British Society for Antimicrobial Chemotherapy

brief-report

The effect of aminoglycoside-induced adaptive resistance on the antibacterial activity of other antibiotics against Pseudomonas aeruginosa in vitro

Murray L. Barclaya, Evan J. Begga, Stephen T. Chambersb and Barbara A. Peddiec

aDepartments of Clinical Pharmacology, Christchurch Hospital Christchurch, New Zealand bInfectious Diseases, Christchurch Hospital Christchurch, New Zealand cNephrology, Christchurch Hospital Christchurch, New Zealand

Received 21 March 1996; returned 15 April 1996; accepted 17 May 1996

The effect of gentamicin-induced adaptive resistance on the antibacterial activity of six non-aminoglycoside antibiotics was studied. Adaptive resistance was induced in Pseudomonas aeruginosa in a dynamic in-vitro model of infection. The bactericidal effect of ceftazidime, imipenem, aztreonam, ciprofloxacin, and piperacillin was not altered in the presence of adaptive resistance but the effect of rifampicin was increased.


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