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Journal of Antimicrobial Chemotherapy (1996) 37, 999-1003
© 1996 The British Society for Antimicrobial Chemotherapy

brief-report

Evaluation of the Etest for rapid susceptibility testing of Mycobacteriumavium to clarithromycin

Léa Lebruna, Catherine Onodya, Véronique Vincentb and Patrice Nordmannb

aService de Bactéreiologie-Virologie, Hôpital Antoine Béclè;re Clamart Faculté de Medecine Paris-Sud 157 rue de la Porte de Trivaux 92141 Clamart Cédex, France bCentre National de Référence des Mycobactéries, Institut Pasteur 75015 Paris, France

Received 3 October 1995; returned 2 January 1996; accepted 5 February 1996

MICs of clarithromycin were determined by the Etest method for thirty clinical strains of Mycobacterium avium complex (MAC) and compared with MICs results as determined by the reference agar dilution method. Agreement (within±1 log2 dilution) between the Etest and the reference method was 70% for susceptible strains and 100% for resistant strains. No major errors resulting in misclassification in susceptibility or resistance categories were detected for the Etest MIC method. It is suggested that the Etest is easy to perform and is an accurate method for determining susceptibility of MAC strains to clarithromycin.


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[Abstract] [Full Text]


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