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Journal of Antimicrobial Chemotherapy (1996) 37, 993-998
© 1996 The British Society for Antimicrobial Chemotherapy

brief-report

The effect of rifampicin on adaptive resistance of Pseudomonas aeruginosa to aminoglycosides

Y. Q. Xiong, J. Caillon, H. Drugeon, G. Potel* and D. Baron

Laboratoire d' Antibiologie Clinique et Expérimental, Faculté de Médecine, Centre Hospitalier Universitaire 44035 Nantes, France

Received 12 October 1995; returned 6 December 1995; accepted 22 January 1996

*Corresponding author

Using the dynamic chequerboard technique, we confirmed that rifampicin produces a synergistic bactericidal effect when combined with amikacin or netilmicin. Adaptive resistance was suppressed when rifampicin was added to aminoglycoside after, but not during, first exposure to amikacin or netilmicin. The effect of rifampicin on adaptive resistance could account for the synergy between rifampicin and aminoglycosides.


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