Journal of Antimicrobial Chemotherapy (1996) 37, 1017-1021
© 1996 The British Society for Antimicrobial Chemotherapy
brief-report |
Concentration of teicoplanin in the serum of adults with end stage chronic renal failure undergoing treatment for infection
aDepartment of Nephrology, H;ôpital Ed. Herriot 69437Lyon Cedex 03, France bDepartment of Haemodialysis, H;ôpital Ste Marguerite 13009 Marseille, France cPharmacology Department, H;ôpital Saint-Eloi 34295 Montpellier, France dBacteriological Service, H;ôpital Saint-Eloi 34295 Montpellier, France
Received 11 July 1995; returned 21 September 1995; accepted 6 December 1995
We examined the adequacy of the following schedule for the administration of iv teicoplanin to patients with chronic renal failure: three doses of 6 mg/kg at 12 h intervals, a fourth dose 24 h later and then subsequent doses every 72 h. Eight infected patients undergoing dialysis were investigated, with serum antibiotic concentrations measured ten minutes before and one hour after administration. Mean trough concentrations were 6.9±3.1 mg/L on day two, 9.8±4.4 mg/L (day three), 9.2±4.8 mg/L (day six), 10.9±5.5 mg/L (day nine), 12.1±6.1 mg/L (day 12) and 14.8±8.0 mg/L (day 15). The proposed schedule achieved adequate trough serum teicoplanin concentrations by 48 h in six out of eight patients examined. The dosage regimen was well tolerated.