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Journal of Antimicrobial Chemotherapy (1996) 37, 1011-1016
© 1996 The British Society for Antimicrobial Chemotherapy

brief-report

Comparative in-vitro activity of the new fluoroquinolone trovafloxacin (CP-99,219) against Gram-positive cocci

Teresa M. Coquea, Kavindra V. Singha and Barbara E. Murray*,a,b

aDivision of Infectious Diseases, Departments of Internal Medicine, The University of Texas Medical School Houston, Texas 77030, USA bMicrobiology and Molecular Genetics1, The University of Texas Medical School Houston, Texas 77030, USA

Received 13 June 1995; returned 31 August 1995; accepted 8 January 1996

*Corresponding author Barbara E. Murray, M.D., University of Texas Medical School, Division of Infectious Diseases, 6431 Fannin, Room 1.728 JFB, Houston, TX 77030, USA. Phone: +1-713-792-4929; Fax: +1-713-745-0130

The in-vitro activities of the new fluoroquinolone trovafloxacin (CP-99,219) and ciprofloxacin were determined against 225 Gram-positive cocci. Trovafloxacin was 4–32 fold more active than ciprofloxacin against staphylococci and streptococci and also showed greater activity against enterococci including vancomycin resistant Enterococcus faecium and Enterococcus faecalis that were highly resistant to aminoglycosides and/or produced ß-lactamase. Trovafloxacin was also bactericidal at 3 mg/L against enterococci except for isolates for which the MICs were ≥2 mg/L.


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