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Journal of Antimicrobial Chemotherapy (1996) 37, 1005-1009
© 1996 The British Society for Antimicrobial Chemotherapy

brief-report

In-vitro activity of psychiatric drugs against Corynebacterium urealyticum (Corynebacterium group D2)

J. L. Muñioz-Bellido, S. Muñioz-Bellido and J. A. García-Rodrfguez*

Departamento de Microbiologia y Parasitologia, Hospital Universitario de Salamanca Paseo de San Vicente 108, 37007 Salamanca, Spain

Received 15 September 1995; returned 6 December 1995; accepted 18 January 1996

*Corresponding author

We tested the in-vitro activity of amoxycillin, amoxycillin/clavulanic acid, cefotaxime, gentamicin, trimethoprim-sulphamethoxazole, tetracycline, norfloxacin, ciprofloxacin, vancomycin, teicoplanin, clindamycin and five psychiatric drugs (chlorpromazirje, sertraline, fluoxetine, paroxetine and risperidone) against 32 strains of Corynebacterium urealyticum. Resistance rates exceeded 90% for all antibiotics except glycopeptides, quinolones and tetracycline. Sertraline was the most active psychiatric drug. We tested the influence of sertraline on the activity of amoxycillin, amoxycillin/clavulanic acid, cefotaxime, gentamicin, trimethoprim-sulphamethoxazole, tetracycline and ciprofloxacin. We did not observe antagonism in any case. Sertraline enhanced the activity of ciprofloxacin and tetracycline against all strains (MIC decrease: 4–64-fold for ciprofloxacin, 2–32-fold for tetracycline).


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