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Journal of Antimicrobial Chemotherapy (1996) 37, 617-622
© 1996 The British Society for Antimicrobial Chemotherapy

brief-report

Combination of 5-flucytosine and capsule-binding monoclonal antibody in the treatment of murine Cryptococcus neoformans infections and in vitro

Marta Feldmessera, Jean Mukherjeeb and Arturo Casadevalla,c,*

aDivision of Infectious Diseases, Department of Medicine, Albert Einstein College of Medicine 1300 Morris Park Ave, Bronx, NY 10461, USA bDepartment of Cell Biology, Albert Einstein College of Medicine 1300 Morris Park Ave, Bronx, NY 10461, USA cDepartment of Microbiology and Immunology, Albert Einstein College of Medicine 1300 Morris Park Ave, Bronx, NY 10461, USA

Received 13 February 1995; returned 27 July 1995; accepted 2 October 1995

*Corresponding author

The efficacy of combination therapy with 5-flucytosine and an IgGl monocional antibody to Cryptococcus neoformans capsular glucuronoxylomannan was studied in vitro with J774.16 murine macrophage-like cells and in vivo in murine cryptococcal infection. The combination of 5-flucytosine and IgGl was more effective in reducing the numbers of C. neoformans colony-forming units in vitro and in vivo than either agent alone.


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