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Journal of Antimicrobial Chemotherapy (1996) 37, 575-581
© 1996 The British Society for Antimicrobial Chemotherapy

research-article

Efficacy of norfloxacin and doxycycline for treatment of Vibrio cholerae O139 infection

D. Duttaa, S. K. Bhattacharyaa, M. K. Bhattacharyaa, A. Deba, M. Deba, B. Mannaa, A. Moitrab, A. K. Mukhopadhyaya and G. B. Naira

aNational Institute of Cholera and Enteric Diseases P-33, C.I.T. Road, Scheme-XM, Beliaghata, Calcutta 700010 bInfectious Diseases Hospital Beliaghata, Calcutta 700 010, India

Received 9 March 1995; returned 2 August 1995; accepted 16 October 1995

An open randornised controlled clinical trial with 160 adults with acute watery diarrhoea and severe dehydration compared the efficacy of varying regimens of norfloxacin and doxycycline for the treatment of cholera caused by Vibrio cholerae O139 Bengal. Data were analysed for the 111 patients who were faeces culture positive for V. cholerae O139. In addition to rehydration therapy, 28 patients received 300 mg of doxycycline as a single dose on admission, 26 patients received norfloxacin 400 mg bd for three days, 28 patients received a single dose of 800 mg of norfloxacin and 29 patients received no antibiotic (control group). Patients in the three treatment groups and control group had comparable characteristics on admission. All three treatment groups had reduced stool output, duration of diarrhoea and fluid intake compared with the control group. Multidose norfloxacin treatment significantly reduced stool output, duration of diarrhoea and fluid requirement compared with the other regimens.


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