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Journal of Antimicrobial Chemotherapy (1996) 37, 383-387
© 1996 The British Society for Antimicrobial Chemotherapy

brief-report

Lack of interaction between valaciclovir, the L-valyl ester of acyclovir, and Maalox antacid

Florence de Bonya, Roselyne Bidaulta, Richard Peckb and John Posnerb

aDepartment of Clinical Pharmacology, Laboratories Wellcome 20 rue Rouget de Lisle, 92 442 Issy les Moulineaux Cedex, France bDepartment of Clinical Pharmacology, The Wellcome Research Laboratories Langley Court, Beckenham, Kent BR3 3BS, UK

Received 13 June 1995; returned 25 August 1995; accepted 28 September 1995

Valaciclovir is rapidly and extensively converted to acyclovir. In this study we investigated the potential interaction between oral valaciclovir and Maalox. On each of three occasions 18 healthy volunteers received a single oral dose of 1000 mg valaciclovir, or 30 mL Maalox 65 min after valaciclovir administration, or 30 mL Maalox 30 min before valaciclovir. Acyclovir plasma concentrations and pharmacokinetic parameters were not significantly affected by administration of Maalox before or after valaciclovir. Therefore, there is no need for restriction of valaciclovir dosing in patients receiving antacid medication.


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