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Journal of Antimicrobial Chemotherapy (1996) 37, 341-344
© 1996 The British Society for Antimicrobial Chemotherapy

brief-report

Outer membrane permeability of non-typable Haemophilus influenzae

Laura Sáncheza,b, Marta Puigb,a, Carme Fustéa, José Loréna and Miquel Viñasa,b,*

aDepartment of Microbiology and Parasitology, Health Sciences Division, University of Barcelona 08028 Barcelona bLaboratory of Microbiology, Institut Universitari de Salut Publica de Catalunya Feixa Llarga S/N, L'Hospitalet de Llobregat. 08907, Spain

Received 16 February 1995; returned 2 August 1995; accepted 20 September 1995

*Corresponding author Dr Miquel Vifias, Department of Microbiology and Parasitology, Health Sciences Division, School of Pharmacy, University of Barcelona. 08028, Barcelona, Spain

The permeability to cephaloridine was studied in five Haemophilus influenzae strains (four non-typable and one type b) using the Zimmermann and Rosselet method. The ß-lactamase activity was due to a plasmid-encoded TEM-1 enzyme. High permeability coefficients were measured in all strains examined. No great differences in permeability coefficients were found, even between strains with marked differences in OMP electrophoretic profiles.


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