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Journal of Antimicrobial Chemotherapy (1996) 37, 331-339
© 1996 The British Society for Antimicrobial Chemotherapy

research-article

Distribution of cefdinir, a third generation cephalosporin antibiotic, in serum and pulmonary compartments

Peter J. Cooka, Jenny M. Andrewsb, Richard Wiseb and David Honeybournea

aDepartment of Thoracic Medicine, City Hospital Dudley Road, Birmingham B18 7QH, UK bDepartment of Microbiology, City Hospital Dudley Road, Birmingham B18 7QH, UK

Received 12 January 1995; returned 3 April 1995; accepted 13 September 1995

The distribution of a new cephalosporin, cefdinir, in serum, epithelial lining fluid (ELF), bronchial mucosa and alveolar macrophages was studied in 17 adults following a single oral dose of 300 or 600 mg of cefdinir; tissue samples being obtained by diagnostic bronchoscopy approximately 4 h after this dose. Mucosal biopsies were taken, alveolar macrophages harvested by lavage, and ELF volume derived from urea concentrations in bronchial lavage fluid and blood. A microbiological assay for cefdinir was performed in serum, bronchial mucosa, ELF and alveolar macrophages. In patients taking 300 mg of cefdinir, the median concentrations of cefdinir were 2.00 mg/L (range 1.40–8.00) in serum, 0.78 mg/L (range 0–1.33) in bronchial mucosa, and 0.29 mg/L (range 0–4.73) in ELF. In patients taking 600 mg, the median concentrations were 4.20 mg/L (range 3.05–6.40) in serum, 1.14 mg/L (range 0–1.92) in bronchial mucosa, and 0.49 mg/L (range 0–0.59) in ELF. Cefdinir did not penetrate macrophages.


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