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Journal of Antimicrobial Chemotherapy (1995) 36, 851-855
© 1995 The British Society for Antimicrobial Chemotherapy

in-brief

The effect of burn wound surgery and teicoplanin on the bactericidal activity of polymorphonuclear leucocytes against Staphylococcus aureus

J. A. Steer*, G. B. Hill and A. P. R. Wilson

Department of Clinical Microbiology, University College Hospital Grafton Way, London, WC1E 6AU, UK

Received 3 January 1995; returned 27 March 1995; accepted 25 June 1995

*Tel: +44-(0)171-380-9515; Fax: +44-(0)171-388-8514.

Polymorphonuclear leucocyte (PMN) function is suppressed for several weeks after burn injury, rendering patients susceptible to infection, commonly with Staphylococcus aureus. A study was performed to determine the effects of surgery to the burn wound and antimicrobial prophylaxis with teicoplanin on killing of S. aureus by PMNs taken from burn patients. The bactericidal rate was significantly reduced before surgery compared to controls (P<0.01 Mann Whitney), but neither surgery nor teicoplanin had any significant additional effect on the bactericidal rate. The bactericidal rate of PMNs did not have any significant effect on clinical outcome following surgery.


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