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Journal of Antimicrobial Chemotherapy (1995) 36, 827-831
© 1995 The British Society for Antimicrobial Chemotherapy

brief-report

Inhibition of Helicobacter pylori growth by 4-hydroxy-2-alkyl-quinolines produced by Pseudomonas aeruginosa

Sandra L. Laceya,*, Senel Mehmea,{dagger} and Graham W. Taylorb,{ddagger}

aDepartment of Infectious Diseases and Bacteriology bDepartment of Clinical Pharmacology, Royal Postgraduate Medical School Du Cane Road, London W12 ONN, UK

Received 22 November 1994; returned 8 March 1995; accepted 12 June 1995

*Present address: Redbridge Health Care, King Georges Hospital, Barley Lane, Goodmayes, Essex IG3 8YB, UK.

4-Hydroxy-2-alkylquinolines produced by Pseudomonas aeruginosa can inhibit the growth of both metronidazole-sensitive and resistant strains of Helicobacter pylori in vitro. The MIC of one analogue, 4-hydroxy-2-heptylquinoline, was determined by agar plate incorporation as 0.1–0.5 mg/L which compares favourably with other anti-helicobacter agents.


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