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Journal of Antimicrobial Chemotherapy (1995) 36, 821-825
© 1995 The British Society for Antimicrobial Chemotherapy

brief-report

Characterization of vancomycin resistance in Enterococcus durans

E. Cercenado*, S. Ünala, C. T. Eliopoulosa, L. G. Rubinb, H. D. Isenbergb, R. C. Moellering, Jra and G. M. Eliopoulosa

aDeaconess Hospital, Boston, Massachusetts 02215 and Harvard Medical School Boston, Massachusetts 02115 bLong Island Jewish Medical Center, the Long Island Campus for Albert Einstein College of Medicine, New Hyde Park New York 11042, USA

Received 3 February 1995; returned 10 May 1995; accepted 26 June 1995

*Correspondence address: Dr Emilia Cercenado, Servicio de Microbiologia, Hospital General Gregorio Maranon, Dr. Esquerdo 46, 28007 Madrid, Spain. Tel: + 34-(91)-5868453 Fax: + 34-(91)-5868018.

During investigation of an outbreak of vancomycin resistant Enterococcus faecium in a paediatric hospital, an isolate of Enterococcus durans resistant to vancomycin, teicoplanin, ampicillin and highly resistant to gentamicin and streptomycin was found in the stools of a patient also colonized with a strain of E. faecium with the same resistance pattern. Minimal inhibitory concentrations of vancomycin and teicoplanin were 512 and 64 mg/mL, respectively. Resistance to vancomycin as well as high-level resistance to gentamicin was transferable to an E. faecium recipient strain. Both multiresistant E. faecium and E. durans isolates as well as the transconjugant presented only one plasmid. The vanA gene was detected and localized to the high molecular weight plasmid by DNA hybridization with a vanA gene probe. Growth in vancomycin resulted in induction of an approximately 40 kDa protein visible in membrane preparations from these cells. Genetic linkage between vancomycin and gentamicin resistance genes in the same plasmid is suggested.


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