Journal of Antimicrobial Chemotherapy (1995) 36, 781-786
© 1995 The British Society for Antimicrobial Chemotherapy
research-article |
Tests for susceptibility of Streptococcus pneumoniae to cefdinir: proposed interpretive criteria and quality control parameters for broth microdilution and disc diffusion methods
aDepartment of Pathology, St. Vincent Hospital and Medical Center Portland, Oregon 97225 bDepartment of Pathology, The Clinical Microbiology Institute Tualatin, Oregon 97062 cDepartment of Pathology, Centers for Disease Control Atlanta, Georgia 30333 dDepartment of Pathology, Indiana University Medical Center Indianapolis, Indiana 46202 eDepartment of Pathology, The University of Texas, Health Science Center San Antonio, Texas 78284 fDepartment of Pathology, Washington University St. Louis, Missouri 63110, USA
Received 10 May 1995; accepted 20 June 1995
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Proposed quality control (QC) parameters for susceptibility testing of Streptococcus pneumoniae to cefdinir were developed following the procedure recommended by the National Committee for Clinical Laboratory Standards. The proposed QC MIC range for microdilution susceptibility testing of S. pneumoniae ATCC 49619 is 0.06–0.25 mg/L. The proposed QC limits for inhibitory zone diameters of S. pneumoniae ATCC 49619 around 5 µg cefdinir disks is 26–31 mm. We recommend the following for tentative interpretive criteria for determining the susceptibility of S. pneumoniae to cefdinir: susceptible, MIC 
0.5 mg/L or inhibition zone diameter 23 mm; intermediate, MIC 1.0 mg/L or inhibition zone, 20–22 mm; resistant, MIC 2.0 mg/L or inhibition zone diameter, 
19 mm for broth microdilution and disc diffusion tests, respectively.