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Journal of Antimicrobial Chemotherapy (1995) 36, 723-728
© 1995 The British Society for Antimicrobial Chemotherapy

brief-report

Sulfadoxine/pyrimethamine or chloroquine/clindamycin treatment of Gabonese school children infected with chloroquine resistant malaria

Wolfram Metzgera,b, Benjamin Mordmüllera,c, Wolfgang Graningerc, Ulrich Bienzleb and Peter G. Kremsnera,c,*

aInternational Research Laboratory Albert-Schweitzer-Hospital, B.P. 118 Lambarene, Gabon; bInstitut fur Tropenmedizin Engeldamm 62, 10179 Berlin, Germany; cDepartment of Infectious Diseases University of Vienna, Währinger Gürtel 18, 1090 Vienna, Austria

returned 11 November 1994; accepted 16 February 1995

*Corresponding author: Tel: +49-(30)-274-6116; Fax: +49-(30)-274-6736.

In a randomized trial, a high dosage chloroquine monotherapy (45 mg/kg over 3 days) was compared with combination regimens of sulfadoxine/pyrimethamine and chloroquine/clindamycin for treating Gabonese school children with Plasmodium falciparum malaria. In chloroquine treated patients only 32% were ultimately cured. In contrast, more than 90% of patients were cured after treatment with either combination regimen.


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