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Journal of Antimicrobial Chemotherapy (1995) 36, 717-721
© 1995 The British Society for Antimicrobial Chemotherapy

brief-report

Enteric absorption of ciprofloxacin during the immediate postoperative period

Stephen M. Cohn, Kelly A. Cohn, Michael J. Rafferty, Andrew H. Smith, Linda C. Degutis, Steven F. Kowalsky and Anita Shah

Section of Trauma/Surgical Critical Care, Department of Surgery Yale School of Medicine, 350 Congress Avenue, Suite 3A, New Haven, CT 06510, USA

returned 24 March 1995; accepted 26 May 1995

We studied the enteric absorption of ciprofloxacin immediately following major abdominal surgery to determine if this drug could replace parenteral agents. Nine critically ill subjects received ciprofloxacin, 750 mg, every 12 h for 48 h via nasogastric tube. Drug concentrations were measured after the first and fourth doses. There was insignificant absorption after the initial dose, Cmax = 0.6 ± 0.6 (mg/L) and AUCo-12 = 3.5 ± 3.2 (mg.h/L). Unfortunately, serum ciprofloxacin concentrations were also minimally detectable in three of nine subjects after the fourth dose. Enteric absorption of ciprofloxacin, therefore, was erratic and unpredictable in critically ill patients following major abdominal surgery.


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