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Journal of Antimicrobial Chemotherapy (1995) 36, 713-716
© 1995 The British Society for Antimicrobial Chemotherapy

brief-report

In-vitro antifungal activity of sertaconazole, econazole, and bifonazole against Candida spp

A. J. Carrillo-Muñioz* and J. M. Torres-Rodriguez

Laboratori de Micologia Institut Municipal d' Investigacio Medica Universitat Autonoma de Barcelona Avda. Dr. Aiguader 80 Barcelona, Spain

returned 12 April 1995; accepted 24 May 1995

*Correspondence to: Dr A. J. Carrillo-Munoz, Valle de Ordesa 4, 4°, 4a, 08031 Barcelona, Spain.

The in-vitro activity of sertaconazole (7-chloro-3-[l-(2,4-dichlorophenyl-l-yl)ethoxy-methyl] benzo[b]] thiophene) was compared with that of econazole and bifonazole against 150 strains of yeasts which includes six Candida species. Minimum inhibitory concentrations (MICs) were determined by a microdilution technique in Sabouraud's liquid medium, (pH 5.6). Sertaconazole (arithmetic mean MIC 0.77 mg/L) was more active than econazole (MIC 1.75 mg/L) and bifonazole (MIC 9.05 mg/L). MIC values for sertaconazole were generally and specifically lower for each tested species, Candida parapsilosis being the most susceptible (MIC 0.31 mg/L), in contrast to Candida tropicalis, which had the highest MIC (1.67 mg/L).


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