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Journal of Antimicrobial Chemotherapy (1995) 36, 707-711
© 1995 The British Society for Antimicrobial Chemotherapy

brief-report

In-vitro activities of various antibiotics, alone and in combination with amikacin against Pseudomonas aeruginosa

A. Alev Gerçekera and Bülent Gürlerb

aDepartment of Pharmaceutical Microbiology, Faculty of Pharmacy Faculty of Medicine, University of Istanbul, Istanbul 34452, Turkey bDepartment of Microbiology and Clinical Microbiology Faculty of Medicine, University of Istanbul, Istanbul 34452, Turkey

returned 4 October 1994; accepted 24 November 1994

The in-vitro activities of various antibiotics, either alone or in combination with amikacin were assessed in clinical isolates of Pseudomonas aeruginosa. Clinically relevant synergic interactions were most frequent with piperacillin (92%), ceftazidime (87%) and aztreonam (84%), and less frequent with imipenem (35%). Ciprofloxacin-amikacin showed only an additive effect.


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