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Journal of Antimicrobial Chemotherapy (1995) 36, 703-706
© 1995 The British Society for Antimicrobial Chemotherapy

brief-report

Activity of sucralfate (sucrose octa-sulphate), an anti-ulcer agent, against opportunistic Gram-negative bacilli

S. G. L. Bragmana, C. L. Pankhurstb and M. W. Casewella

aDulwich Public Health Laboratory and Medical Microbiology Bessemer Road, London SE59RX, UK bDepartment of Oral Microbiology King's College School of Medicine and Dentistry, Bessemer Road, London SE59RX, UK

returned 7 February 1995; accepted 20 May 1995

The in-vitro activity of sucralfate (sucrose octa-sulphate) in suspension was examined against 128 strains of Gram-negative bacilli. Inhibitory activity was demonstrated against all isolates and bactericidal activity was demonstrated for 68. Sucralfate has inhibitory and bactericidal antibacterial activity which may contribute to its in-vivo clinical efficacy.


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