Journal of Antimicrobial Chemotherapy (1995) 36, 657-663
© 1995 The British Society for Antimicrobial Chemotherapy
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Multiple dose pharmacokinetics of an oral solution of itraconazole in patients receiving chemotherapy for acute myeloid leukaemia
aDepartment of Haematology Derriford Hospital, Plymouth PL6 SDH; bPHLS Mycology Reference Laboratory Public Health Laboratory, Bristol BS2 8EL; cDepartment of Haematology Musgrove Park Hospital, Taunton TA1 5DB; dDepartment of Haematology Rotherham District General Hospital, Rotherham S602UD, UK
returned 22 November 1994; accepted 5 May 1995
*Corresponding author
The multiple dose pharmacokinetics of a solution of itraconazole given orally were measured in an open study of 20 patients undergoing remission induction chemotherapy for acute myeloid leukaemia. Patients were given itraconazole 5 mg/kg od, 2.5 mg/kg bd, 2.5 mg/kg odor 1.25 mg/kg bd. The mean daily dose of itraconazole was 407 mg for patients receiving 5 mg/kg/day and 148 mg in patients receiving 2.5 mg/kg/day. Mean concentrations of 493 and 495 µ/L were achieved on day 8 in patients who received 5 mg/kg/d od or 2.5 mg/kg bd itraconazole respectively. However, mean concentrations were significantly lower for those who received 2.5 mg/kg od itraconazole being 110 µg/L on day 8. Mean areas under the serum-concentration time curves were also markedly higher in patients receiving 5 mg/kg/day than in those receiving 2.5 mg/kg/day itraconazole and were 22,382 and 5615 µg.h/L on day 15 respectively. These findings suggest that the serum concentrations attained with an oral solution of 5 mg/kg itraconazole either once daily or in two divided doses are suitable for antifungal prophylaxis in patients receiving chemotherapy for acute myeloid leukaemia.
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