Journal of Antimicrobial Chemotherapy (1995) 36, 647-656
© 1995 The British Society for Antimicrobial Chemotherapy
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Comparative activity of azithromycin and doxycycline against Brucella spp. infection in mice
aDpto. de Microbiologia Clinica Universitaria de Navarra, 31080 Pamplona, Spain bDpto. de Farmaciay Tecnologia Farmacéutica 31080 Pamplona, Spain cDpto. de Microbiologia Universidad de Navarra 31080 Pamplona, Spain
returned 29 December 1994; accepted 25 May 1995
*Corresponding author. E-mail: cgamazo{at}mail2.cti.unav.es
The activities of a short therapeutic regimen with azithromycin and the classic treatment doxycycline with streptomycin were compared and evaluated in mice infected with Brucella melitensis. In a chronic model, starting therapy 31 days after challenge, azithromycin (10 days, 50 mg/kg/day) significantly reduced the infection (2.9 logs, day 48 post-infection). The effectiveness of doxycycline (21 days, 50mg/kg/12 hourly) was greater than azithromycin (4.1 logs of reduction, day 48 post-infection), and when doxycycline was administered for a period of 45 days, all the animals were bacteriologically cured from day 78. The combination with streptomycin (14 days, 10 mg/kg/day) did not improve the effect of any of the regimens. In an acute model infection, treatments with doxycycline or doxycycline-streptomycin, for a period of 3 days, starting 1 day after lethal challenge, were able to protect all the mice. In contrast, only 50% of the mice treated with azithromycin survived the challenge. In conclusion, although a short oral treatment with azithromycin was able to reduce the infection significantly, it was not able to cure the animals as effectively as the classic regimen with doxycycline administered for a longer period of time.
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