Journal of Antimicrobial Chemotherapy (1995) 36, 41-52
© 1995 The British Society for Antimicrobial Chemotherapy
research-article |
Sequence analysis of two chromosomally mediated inducible ß-lactamases from Aeromonas sobria, strain 163a, one a class D penicillinase, the other an AmpC cephalosporinase
aDepartment of Microbiology and Pathology, School of Medical Sciences, University of Bristol Bristol BS8 1TD, UK bDepartment of Biochemstry, School of Medical Sciences, University of Bristol Bristol BS8 1TD, UK cRegional Antimicrobial Reference Laboratory, Southmead Health Services NHS Trust, Bristol BS10 5NB, UK
Received 18 August 1994; returned 7 November 1994; accepted 31 January 1995
Two ß-lactamase genes from Aeromonas sobria, strain 163a, have been cloned and sequenced, one encoding a typical class C cephalosporinase, designated CepS, the other a class D penicillinase, designated AmpS. CepS is predicted to be a mature protein of 38 kDa with a pi value of 7.0. The amino acid sequence of CepS is most similar to that ofAmpC from Pseudomonas aeruginosa (54.7%). AmpS is predicted to be a mature protein of 27 kDa with a pi value of 7.9 that mostly closely resembles BLAD from Klebsiella pneumoniae (42.2%), and OXA-1from Escherichia coli (36.6%), ß-lactamases that are encoded by genes carried on multiresistant transposons. AmpS differs significantly from the other class D ß-lactamases in that it hydrolyses cloxacillin poorly and is inducible. Both genes exhibit a high overall GC content and possess a high NNC and NNG codon preference, similarto that of genes from Pseudomonas spp.
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