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Journal of Antimicrobial Chemotherapy (1995) 36, 253-258
© 1995 The British Society for Antimicrobial Chemotherapy

brief-report

Ampicillin plus ciprofloxacin therapy of experimental endocarditis caused by multidrug-resistant Enterococcus faecium

David Landman, John M. Quale, Neville Mobarakai and Mohammad M. Zaman

Department of Medicine (1 I IE), Department of Veterans Affairs Medical Center 800 Poly Place, Brooklyn, New York 11209, USA

Received 5 July 1994; returned 11 November 1994; accepted 13 February 1995

The combination of ampicillin and ciprofloxacin displayed bactericidal in-vitro activity against two strains of Enterococcus faecixan which were highly resistant to ampicillin, vancomycin, and aminoglycosides. This antibiotic combination wasused to treat rabbits with experimental endocarditis caused by these strains. Although a significant decrease in vegetation bacterial counts occurred with one strain, the degree of killing did not approach that of penicillin with an aminoglycoside against susceptible enterococci.


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