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Journal of Antimicrobial Chemotherapy (1995) 36, 247-251
© 1995 The British Society for Antimicrobial Chemotherapy

brief-report

An investigation of the pharmacokinetics and autoinduction of rifabuting metabolism in mice treated with 10 mg/kg/day six times a week for 8 weeks

M. Strolin Benedetti, E. Pianezzola, G. Brianceschi, D. Jabes, C. Delia Bruna, M. Rocchetti and I. Poggesi

Pharmacia-Farmitalia Carlo Erba Via Papa Giovanni XXIII, 23-20014 Nerviano (Milan), Italy

Received 4 July 1994; returned 11 October 1994; accepted 8 January 1995

Plasma, lung and spleen concentrations of rifabutin have been measured in mice after single and multiple oral administrations of the drug. Rifabutin concentrations in spleen were similar to those measured in plasma, whereas concentrations inlung were higher. No significant autoinduction of rifabutin metabolism was observed.


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